Overview
This summer school aims at providing guidelines on optimal practice in designing, analyzing, and interpreting genetic epidemiological studies, for those who would like to actively analyze DNA sequencing from whole genome sequencing or whole exome sequencing studies (NGS), genome-wide association studies (GWAs), candidate gene or even single genetic marker studies. Knowledge and awareness about all steps of a genetic epidemiological study, including planning, data preparation, quality control or statistical analysis will be considered as this is crucial for the cost-efficient use of these data. Special attention will be given to data generation and quality control procedures of sequencing and genotyping technologies. Confounding due to population heterogeneity, i.e., population stratification, or multi-ethnic populations and cryptic relatedness are important in genetic studies. Approaches to take these challenges into account will be discussed. The concepts of imputing missing genotypes and haplotype inference will be explained. Replication and meta-analysis are commonly used in genetic epidemiological studies, and these concepts will be introduced. Finally, Mendelian randomization and the underlying assumptions will be explained.
Learning outcomes
Define the basics of molecular genetics
Recognize modes of inheritance from pedigrees
Describe the most important study designs for association analysis: case-control and cohort designs, designs for quantitative traits
Understand the problems of population stratification and cryptic relatedness
Explain the most important genetic marker types and their characteristics
List the most important genotyping technologies
Discuss the quality control procedures and measures for the different genotyping technologies
Conduct simple association analyses
Estimate genetic effects
Calculate required sample sizes for association studies
Understand the concept of genotype imputation and haplotype-based analyses
Describe the problem of multiple testing with genetic data
Describe the concept of meta-analysis with genetic data
Describe the concept of Mendelian randomization studies
Describe the most important concepts for gene-based analyses using rare variants
Registration
Registration is open and through the Swiss Institute of Bioinformatics
Accommodation suggestions
Hotel Strela offers an attractive unit price for course participants with an additional reduction if rooms are shared. Two types of double rooms are available for single or double use. The package price offered by Hotel Strela is for three days and includes breakfast. Please, contact the hotel directly to make your reservations. Please, refer to the course when making the reservation.
Additional information
For more information, please, get in contact by:
- Email: info@cardio-care.ch
- Phone: +41 81 410 1801
More information is also available on the website of Swiss Institute of Bioinformatics
COVID safety: we are monitoring the situation. We plan to have the course in person in the biggest lecture room on the Medizincampus in Davos. If changes to this plan are necessary, course participants will be informed in due time.
Financial support
We gratefully acknowledge the financial support of this summer school by
