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Research Interests
1. genetic epidemiology, biomarker studies,
2. machine learning,
3. clinical trials with focus on medical devices,
4. patient–reported outcomes.
Work Experience
Since 2020
Scientific director and CEO of Cardio-CARE, Medizincampus Davos
2004-2019
CEO of StatSol: scientific consulting, statistical consulting, scientific writing
2018-2019
Scientific advisor, AMEDON GmbH, Lübeck
2001-2018
Professor and Head, University Medical Center Schleswig-Holstein – Campus Lübeck, University of Lübeck, Institute of Medical Biometry and Statistics
1995-2001
Scientific employee/assistant professor/university researcher and lecturer (“Hochschuldozent”), Philipps-Universität Marburg, Institute of Medical Biometry and Epidemiology
1994-1995
Assistant professor (“Wissenschaftlicher Assistent”), Philipps-University of Marburg, Institute of Medical Sociology
1992-1994
Scientific employee, Bergische Universität – GH Wuppertal, Department of Economics, Institute of Statistics
Education and Training
2000
Extension of venia legendi by Medical Biometry and Epidemiology, Faculty of Human Medicine, Philipps-Universität Marburg
1998
Habilitation for Genetic Epidemiology, Faculty of Human Medicine, Philipps- Universität Marburg
1994
Doctoral degree (Dr. rer. nat.) in Statistics, Universität Dortmund
1992
Diploma in Statistics, Ludwig-Maximilians-Universität München
Selected Honors and Awards
Since 2022
Group leader at the Swiss Institute of Bioinformatics (SIB)
2019-2024
Accredited Professional Statistician (PSTAT) of the American Statistical Association
Since 2016
Honorary Professor for Biostatistics at the School of Mathematics, Statistics and Computer Science, University of KwaZulu-Natal, South Africa
2014
Leadership Award of the International Genetic Epidemiology Society
2011
Susanne-Dahms-Medaille of the German Region of the International Biometric Society for the special merits in Biometry
2010
Jens-Kirsch-Preis of the German Society of Coloproctology, together with T. Schwandner, W. Kierer, R. Scherer, R. Bouchard, and G. Kolbert for the work “Triple Target Treatment (3T) is more effective than biofeedback alone for anal incontinence: The 3T-AI Study”
2007
Elected member of the International Statistical Institute
2004
Fritz-Linder-Forumpreis of the German Association for Surgery, together with G. Fitze, H. Luksch, I. R. König, H. Görgens, U. Stein, W. Walther, M. Gossen, and H. K. Schackert for the work “Association of functional haplotypes of the RET-Protooncogene promotor with Morbus Hirschsprung”
1999
Certificate “Epidemiology” of the German Epidemiological Association
1999
Certificate “Biometry in Medicine” of the German Association of Medical Informatics, Biometry and Epidemiology and the German Region of the International Biometric Society
Selected Activities in Scientific Societies
2013-2020
Member of the Executive Board of the International Biometric Society
2013
President of the International Genetic Epidemiology Society
2011-2012
Chair of the Representative Council of the International Biometric Society
2010-2012
Member of the Presidium of the German Society for Medical Informatics, Biometry and Epidemiology
2009-2010
Speaker of the German full professors for Medical Informatics, Biometry and Epidemiology
2005-2007
President of the German Region of the International Biometric Society
Selected Editorial Activities
Since 2023
Associate editor of Neurology
2021-2023
Book review editor of Biometrical Journal
Since 2012
Member of the editorial board of Human Genetics
2020-2021
Member of the editorial board of Trials
2008-2021
Member of the editorial board of Deutsche Medizinische Wochenschrift
Since 2007
Associate editor of Statistics in Medicine
Since 2006
Member of the editorial board of Methods of Information in Medicine
Since 1998
Associate editor of the Biometrical Journal
Patents
2020
Computing device for estimating the probability of myocardial infarction (Application number WO2022043229A1), Co-Inventor
2003
Use of SNPs of MCH-R for identifying genetic disorders in maintaining the normal body weight. Patent number WO 03/020965 A2, Co-Inventor
Selected Publications
Göpel, W., Kribs, A., Ziegler, A., Laux, R., Hoehn, T., Wieg, C., Siegel, J., Avenarius, S., von der Wense, A., Vochem, M., Groneck, P., Weller, U., Möller, J., Härtel, C., Haller, S., Roth, B. & Herting, E., on behalf of the German Neonatal Network (2011): Avoidance of mechanical ventilation by surfactant treatment of spontaneously breathing preterm infants (AMV): an open-label, randomised, controlled trial. The Lancet, 378, 1627-1634. doi:10.1016/S0140-6736(11)60986-0
Samani N.J., Erdmann J., Hall A.S., Hengstenberg C., Mangino M., Mayer B., Dixon R.J., Meitinger T., Braund P., Wichmann H.–E., Barrett J.H., König I.R., Stevens S., Szymczak S., Tregouet D.–A., Iles M.M., Pahlke F., Pollard H., Lieb W., Cambien F., Fischer M., Ouwehand W., Balmforth A.J., Baessler A., Ball S.G., Strom T.M., Brænne I., Gieger C., Deloukas P., Tobin M.D., Ziegler A., Thompson J.R. & Schunkert H., Wellcome Trust Case Control Consortium, Cardiogenics Consortium (2007): Genomewide association analysis of coronary artery disease. The New England Journal of Medicine, 357, 443–453. doi:10.1056/NEJMoa072366
Wright, M. N. & Ziegler, A. (2017): ranger: a fast implementation of random forests for high dimensional data in C++ and R. Journal of Statistical Software, 77:1.
Ziegler, A. (2011): Generalized estimating equations. Lecture Notes in Statistics. New York:
Springer. ISBN: 978–1–4614–0498–9
Ziegler A., König I.R. (2010): A Statistical Approach to Genetic Epidemiology: Concepts and Applications. With an E–Learning Course by Friedrich Pahlke. 2nd ed. Weinheim: Wiley–
VCH. ISBN: 978–3–527–32389–0
General information about publications:
8 books, more than 500 articles in peer–reviewed journals. Total IF > 2500