Email:
Research Interests
1. genetic epidemiology, biomarker studies,
2. machine learning,
3. clinical trials with focus on medical devices,
4. patient–reported outcomes.
Work Experience
Since 2020
Scientific director and CEO of Cardio-CARE, Medizincampus Davos
2004-2019
CEO of StatSol: scientific consulting, statistical consulting, scientific writing
2018-2019
Scientific advisor, AMEDON GmbH, Lübeck
2001-2018
Professor and Head, University Medical Center Schleswig-Holstein – Campus Lübeck, University of Lübeck, Institute of Medical Biometry and Statistics
1994-2001
Scientific employee/assistant professor (“Wissenschaftlicher Assistent”)/university researcher and lecturer (“Hochschuldozent”), Philipps-Universität Marburg, Center for Methodology and Health Research
1992-1994
Scientific employee, Bergische Universität – GH Wuppertal, Department of Economics, Institute of Statistics
Education and Training
2000
Extension of venia legendi by Medical Biometry and Epidemiology, Faculty of Human Medicine, Philipps-Universität Marburg
1998
Habilitation for Genetic Epidemiology, Faculty of Human Medicine, Philipps- Universität Marburg
1994
Doctoral degree (Dr. rer. nat.) in Statistics, Universität Dortmund
1992
Diploma in Statistics, Ludwig-Maximilians-Universität München
Selected Honors and Awards
Since 2016
Honorary Professor for Biostatistics at the School of Mathematics, Statistics and Computer Science, University of KwaZulu-Natal, South Africa
2014
Leadership Award of the International Genetic Epidemiology Society
2011
Susanne-Dahms-Medaille of the German Region of the International Biometric Society for the special merits in Biometry
1999
Certificate “Epidemiology” of the German Epidemiological Association
1999
Certificate “Biometry in Medicine” of the German Association of Medical Informatics, Biometry and Epidemiology and the German Region of the International Biometric Society
Selected Activities in Scientific Societies
Since 2023
Member of the Board of the Basel Biometric Society
2013-2020
Member of the Executive Board of the International Biometric Society
2013
President of the International Genetic Epidemiology Society
2010-2012
Member of the Presidium of the German Society for Medical Informatics, Biometry and Epidemiology
2005-2007
President of the German Region of the International Biometric Society
Selected Editorial Activities
Since 2023
Associate editor of Neurology
Since 2012
Member of the editorial board of Human Genetics
Since 2007
Associate editor of Statistics in Medicine
Since 2006
Member of the editorial board of Methods of Information in Medicine
Since 1998
Associate editor of the Biometrical Journal
Patents
2020
Computing device for estimating the probability of myocardial infarction (Application number WO2022043229A1), Co-Inventor
2003
Use of SNPs of MCH-R for identifying genetic disorders in maintaining the normal body weight. Patent number WO 03/020965 A2, Co-Inventor
Selected Publications
Betschart, R.O., Riccio, C., Aguilera‑Garcia, D., Blankenberg, S., Guo, L., Moch, H., Seidl, D., Solleder, H., Thalén, F., Thiéry, A., Twerenbold, R., Zeller, T., Zoche, M., Ziegler, A. (2024): Biostatistical aspects of whole genome sequencing studies: pre-processing and quality control. Biometrical Journal, 66, e202300278. doi:10.1002/bimj.202300278
Blankenberg, S., Seiffert, M., Vonthein, R., Baumgartner, H., Bleiziffer, S., Borger, M.A., Choi, Y.-H., Clemmensen, P., Cremer, J., Czerny, M., Diercks, N., Eitel, I., Ensminger, S., Frank, D., Frey, N., Hagendorff, A., Hagl, C., Hamm, C., Kappert, U., Karck, M., Kim, W.-K., König, I.R., Krane, M., Landmesser, U., Linke, A., Maier, L.S., Massberg, S., Neumann, F.-J., Reichenspurner, H., Rudolph, T.K., Schmid, C., Thiele, H., Twerenbold, R., Walther, T., Westermann, D., Xhepa, E. Ziegler, A. Falk, V., DEDICATE-DZHK6 Trial Investigators (2024): Transcatheter or surgical treatment of aortic-valve stenosis. The New England Journal of Medicine, 390, 1572-1583. doi: 10.1056/NEJMoa2400685
Ojeda, F. M., Jansen, M. L., Thiéry, A., Blankenberg, S., Weimar, C., Schmid, M., Ziegler, A. (2023). Calibrating machine learning approaches for probability estimation: A comprehensive comparison. Statistics in Medicine, 42, 5451-5478. doi: 10.1002/sim.9921
Wright, M. N. & Ziegler, A. (2017): ranger: a fast implementation of random forests for high dimensional data in C++ and R. Journal of Statistical Software, 77:1. doi: 10.18637/jss.v077.i01
Ziegler A., König I.R. (2010): A Statistical Approach to Genetic Epidemiology: Concepts and Applications. With an E–Learning Course by Friedrich Pahlke. 2nd ed. Weinheim: Wiley–VCH. ISBN: 978–3–527–32389–0
General information about publications:
8 books, more than 500 articles in peer–reviewed journals. Total IF > 2500
